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Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Article

Bingbing Li, Ying Hong, Yu Gu, Shengjie Ye, Kaili Hu, Jian Yao, Kan Ding, Aihua Zhao, Wei Jia, Houkai Li

Engineering 2022, Volume 9, Issue 2,   Pages 111-122 doi: 10.1016/j.eng.2020.05.023

Abstract: Functional metabolomics is increasingly used to investigate systemic effects on the host by identifyingmechanisms underlying the metabolic benefits of Astragalus polysaccharides (APS) by adopting a functionalmetabolomics strategy., and identified 2-hydroxybutyric acid (2-HB) as a potential functional metabolite for APS activity thatOur results also highlight that functional metabolomics is practical for investigating the mechanism

Keywords： Astragalus     polysaccharides (APS)     Functional metabolomics     2-Hydroxybutyric acid     Obesity    

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Progress in NMR-based metabolomics of

Qifang PAN,Jingya ZHAO,Yuliang WANG,Kexuan TANG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 195-204 doi: 10.15302/J-FASE-2015063

Abstract: Metabolomics has been rapidly developed as an important field in plant sciences and natural productsNMR-based metabolomics has been used in studies of for pathway elucidation, understanding stress responses

Keywords： Catharanthus roseus     monoterpenoid indole alkaloids     NMR     metabolomics    

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Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1604-5

Abstract:

● Metabolomic temporal profiling of cells exposed to xenobiotics.

Keywords： Metabolomics     BPA     MCF-7     Temporal profiling     Metabolic adaption     Dysregulation correlation    

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract: The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolitesDuring the last decade, the progression made in metabolomics has provided insightful information on diseaseRecent studies using metabolomics approach coupled with statistical tools to predict incident diabetes

Keywords： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 58-67 doi: 10.1007/s11684-014-0318-2

Abstract: available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics

Keywords： sepsis     biomarker     genomics     transcriptomics     proteomics     metabolomics    

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High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 651-663 doi: 10.1007/s11684-019-0709-5

Abstract: High-throughput metabolomics can clarify the underlying molecular mechanism of diseases via the qualitativeWe used integrated analysis to communicate the multiple results of metabolomics and network pharmacologyOur study indicated that the combination of high-throughput metabolomics and network pharmacology is

Keywords： metabolomics     liquid chromatography-mass spectrometry     metabolites     metabolic pathways    

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Development and applications of functional gene microarrays in the analysis of the functional diversity

Zhili HE, Joy D. VAN NOSTRAND, Ye DENG, Jizhong ZHOU

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 1,   Pages 1-20 doi: 10.1007/s11783-011-0301-y

Abstract: Functional gene arrays (FGAs) are a special type of microarrays containing probes for key genes involvedin microbial functional processes, such as biogeochemical cycling of carbon, nitrogen, sulfur, phosphorusSeveral generations of GeoChip have been developed and applied to investigate the functional diversity

Keywords： functional gene arrays (FGAs)     GeoChip     microbial communities     functional diversity/composition/structure    

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Fluorescent probes and functional materials for biomedical applications

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 10,   Pages 1425-1437 doi: 10.1007/s11705-022-2163-1

Abstract: Here, we highlight examples of fluorescent probes and functional materials for biological applications

Keywords： fluorescent probes     imaging     cell     biomedicine     biomolecules    

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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Frontiers of Medicine doi: 10.1007/s11684-023-1020-z

Abstract: Retroperitoneal liposarcoma (RLPS) is the main subtype of retroperitoneal soft sarcoma (RSTS) and has a poor prognosis and few treatment options, except for surgery. The proteomic and metabolic profiles of RLPS have remained unclear. The aim of our study was to reveal the metabolic profile of RLPS. Here, we performed proteomic analysis (n = 10), metabolomic analysis (n = 51), and lipidomic analysis (n = 50) of retroperitoneal dedifferentiated liposarcoma (RDDLPS) and retroperitoneal well-differentiated liposarcoma (RWDLPS) tissue and paired adjacent adipose tissue obtained during surgery. Data analysis mainly revealed that glycolysis, purine metabolism, pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue, whereas the tricarboxylic acid (TCA) cycle, lipid absorption and synthesis, fatty acid degradation and biosynthesis, as well as glycine, serine, and threonine metabolism were downregulated. Of particular importance, the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway (PPP) inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib. Our study not only describes the metabolic profiles of RDDLPS and RWDLPS, but also offers potential therapeutic targets and strategies for RLPS.

Keywords： RLPS     proteomics     metabolomics     lipidomics     metabolism    

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Temporal dimension and water quality control in an emission trading scheme based on water environmental functional

Zhaoxing HAN, Zhenyao SHEN, Yongwei GONG, Qian HONG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 1,   Pages 119-129 doi: 10.1007/s11783-011-0272-z

Abstract: Water environmental functional zone (WEFZ) is used to determine the water quality standard and identifyA water quality-control scheme was suggested based on the water quality requirement in the water functional

Keywords： emission trading     water functional zone     water quality control    

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Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

Frontiers of Medicine doi: 10.1007/s11684-023-1022-x

Abstract: The treatment of PML/RARA+ acute promyelocytic leukemia (APL) with all-trans-retinoic acid and arsenic trioxide (ATRA/ATO) has been recognized as a model for translational medicine research. Though an altered microenvironment is a general cancer hallmark, how APL blasts shape their plasma composition is poorly understood. Here, we reported a cross-sectional correlation network to interpret multilayered datasets on clinical parameters, proteomes, and metabolomes of paired plasma samples from patients with APL before or after ATRA/ATO induction therapy. Our study revealed the two prominent features of the APL plasma, suggesting a possible involvement of APL blasts in modulating plasma composition. One was characterized by altered secretory protein and metabolite profiles correlating with heightened proliferation and energy consumption in APL blasts, and the other featured APL plasma-enriched proteins or enzymes catalyzing plasma-altered metabolites that were potential trans-regulatory targets of PML/RARA. Furthermore, results indicated heightened interferon-gamma signaling characterizing a tumor-suppressing function of the immune system at the first hematological complete remission stage, which likely resulted from therapy-induced cell death or senescence and ensuing supraphysiological levels of intracellular proteins. Overall, our work sheds new light on the pathophysiology and treatment of APL and provides an information-rich reference data cohort for the exploratory and translational study of leukemia microenvironment.

Keywords： acute promyelocytic leukemia     plasma proteomics     plasma metabolomics     cross-sectional correlation network    

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A Study of the Functional Mechanism of Petrochemical Engineering Construction Project Management

Ji-ming Wang

Frontiers of Engineering Management 2014, Volume 1, Issue 2,   Pages 129-139 doi: 10.15302/J-FEM-2014020

Abstract: This paper, proceeding from the project construction process, the management mode and the implementation way, makes an in-depth study of the environmental characteristics and the managerial elements of petrochemical engineering construction project, revealing the inherent laws, establishing a theoretical model, and proposing a theory of the mechanisms of construction project management; and presents profound revelations found for construction project management in petrochemical engineering in seven aspects, which can play a guiding role in improving the managerial performance of petrochemical construction project. The theory established proposes that: The construction project management in petrochemical engineering is a complex systematic process, formed of 5 phases and 55 sub-processes of management, and exposed to many factors of influence; the environmental characteristics and managerial elements exercise positive impacts on managerial performance, but different factors have different impacts and act in different ways on managerial performance; the managerial elements of petrochemical engineering construction project are tiered, transferable, systematic and quantifiable, and the role of managerial elements in the managerial performance can be systematically integrated, quantitatively explained and transferred in a multi-level way.

Keywords： petrochemical engineering     construction project     project management     functional mechanism    

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Effects of functional groups for CO

Chenkai Gu, Yang Liu, Weizhou Wang, Jing Liu, Jianbo Hu

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 2,   Pages 437-449 doi: 10.1007/s11705-020-1961-6

Abstract: Functional groups on organic linkers of MOFs play important roles in improving the CO capture abilityfunctionalization effects on CO adsorption were systematically investigated by rationally incorporating various functionalIn addition, three kinds of molecular interactions between CO and functional groups were analyzed andEspecially, our results reveal that –SO H is the best-performing functional group for CO capture in

Keywords： metal-organic frameworks     functional groups     CO2 capture     GCMC     DFT    

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Microbial community and functional genes in the rhizosphere of alfalfa in crude oil-contaminated soil

Yi ZHONG, Jian WANG, Yizhi SONG, Yuting LIANG, Guanghe LI

Frontiers of Environmental Science & Engineering 2012, Volume 6, Issue 6,   Pages 797-805 doi: 10.1007/s11783-012-0405-z

Abstract: vegetated with alfalfa ( L.) to evaluate the rhizosphere effects on the soil microbial population and functionalIn total, 796, 731, and 379 functional genes were detected by microarray in the AR, FR, and NR, respectivelyHigher proportions of functional genes related to carbon degradation and organic remediation, were foundwith NR soil, suggesting that the rhizosphere selectively increased the abundance of these specific functionalanalysis showed that salinity was the most important environmental factor influencing the microbial functional

Keywords： crude oil-contaminated soil     phytoremediation     rhizosphere effects     rhizobox     functional genes    

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Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 178-190 doi: 10.1007/s11684-017-0507-x

Abstract:

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.

Keywords： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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Title Author Date Type Operation

Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through

Bingbing Li, Ying Hong, Yu Gu, Shengjie Ye, Kaili Hu, Jian Yao, Kan Ding, Aihua Zhao, Wei Jia, Houkai Li

Journal Article

Progress in NMR-based metabolomics of

Qifang PAN,Jingya ZHAO,Yuliang WANG,Kexuan TANG

Journal Article

Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Sepsis biomarkers: an omics perspective

Xiao Liu, Hui Ren, Daizhi Peng

Journal Article

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Journal Article

Development and applications of functional gene microarrays in the analysis of the functional diversity

Zhili HE, Joy D. VAN NOSTRAND, Ye DENG, Jizhong ZHOU

Journal Article

Fluorescent probes and functional materials for biomedical applications

Journal Article

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

Journal Article

Temporal dimension and water quality control in an emission trading scheme based on water environmental functional

Zhaoxing HAN, Zhenyao SHEN, Yongwei GONG, Qian HONG

Journal Article

Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

Journal Article

A Study of the Functional Mechanism of Petrochemical Engineering Construction Project Management

Ji-ming Wang

Journal Article

Effects of functional groups for CO

Chenkai Gu, Yang Liu, Weizhou Wang, Jing Liu, Jianbo Hu

Journal Article

Microbial community and functional genes in the rhizosphere of alfalfa in crude oil-contaminated soil

Yi ZHONG, Jian WANG, Yizhi SONG, Yuting LIANG, Guanghe LI

Journal Article

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Journal Article